The neuroscience of gratitude shows it activates brain regions associated with reward, enhancing feelings of contentment & emotional wellbeing.
Regular practice of gratitude can lead to long-term positive changes in the brain, supporting mental health & resilience.
Simple exercises like keeping a gratitude journal can improve mood, increase empathy & strengthen social bonds.
Gratitude is a powerful human emotion.
As researchers explore the neurological underpinnings of gratitude, they’re discovering that this simple practice can lead to profound positive changes in mood, resilience, and overall wellbeing (Russell & Fosha, 2008).
Gratitude, derived from the Latin word gratia, means gratefulness or thankfulness.
Thanking others, thanking ourselves, Mother Nature, or a divine power — gratitude in any form can enlighten the mind and make us feel happier. It has a healing effect on us (Russell & Fosha, 2008).
The benefits of gratitude are endless, and in this article, we explore the neuroscience of gratitude, discuss its scientific basis, and demonstrate how we can use gratitude to improve wellbeing.
Before you continue, we thought you might like to download our five positive psychology tools for free. These detailed, science-based exercises will help you or your clients connect to more positive emotions and enjoy the benefits of gratitude.
In positive psychology, gratitude is how we acknowledge the good things in life. It can be defined as a positive emotional response that we perceive while giving or receiving a benefit from someone (Emmons & McCullough, 2004).
Gratitude is more than just a positive feeling. It is a complex cognitive and emotional phenomenon that involves recognizing how other individuals contribute to our wellbeing and enhance our appreciation of positive outcomes in life.
From a neuroscientific perspective, gratitude activates key regions of the brain such as the prefrontal cortex, the anterior cingulate cortex, the ventral striatum (a key brain region involved in processing rewards), and the insula (a region of the brain involved in emotional awareness; Fox et al., 2015).
Understanding the neuroscience of gratitude and how these areas of the brain regulate emotion, decision-making, and reward processing is an ongoing process. The neuroscience of gratitude is showing that it can impact relationships, resilience, and mental and physical health (Fox et al., 2015).
Essentially, when we experience gratitude, it changes physiological aspects of the brain that reside at the neurotransmitter level (Fox et al., 2015). These changes create feelings of happiness and contentment.
Researchers also hypothesize that gratitude is correlated with brain activity associated with moral cognition. When people are grateful, it activates reward circuits associated with social interaction and social cognitive processes (Fox et al., 2015).
Changes in the posteromedial and insular cortices, medial prefrontal cortex, and nucleus accumbens (a brain region central to the reward system) occur with these moral and social aspects of gratitude (Fox et al., 2015).
The Science of Gratitude: How It Changes the Brain
Science has shown that aspects of gratitude have specific effects on the brain. For example, one study found that making moral decisions about gratitude activated the right anterior superior temporal cortex (Zahn et al., 2008).
This part of the brain is responsible for emotion, autonomic function, memory, and reward-related functions.
Nervous system and emotional states
At a neurobiological level, gratitude regulates the sympathetic nervous system that activates our anxiety responses, and at the psychological level, it conditions the brain to filter the negative ruminations and focus on positive thoughts (Wong et al., 2018).
The limbic system is the part of the brain that is responsible for all emotional experiences. It consists of the thalamus, hypothalamus, amygdala, hippocampus, and cingulate gyrus. Studies have shown that the hippocampus and amygdala, the two main sites regulating emotions, memory, and bodily functioning, get activated with feelings of gratitude (Wong et al., 2018).
This part of the brain includes reward pathways and the hypothalamus, which can boost serotonin and activate the brain stem to produce dopamine, improving mood and making us feel good (Zahn et al., 2008).
Changes in the brain
Research examining specific areas of the brain found that individuals who experience higher levels of gratitude had increased gray matter volume (Zahn et al., 2014). Gray matter is where the brain processes sensation, voluntary movement, perception, speech, learning, and cognitive tasks.
Gratitude can change neural structures in the brain, making individuals feel happier and more content. Feeling grateful and appreciative triggers the “good” hormones and regulates effective functioning of the immune system (Zahn et al., 2008).
It is hypothesized that gratitude activates the reward center of the brain and can alter the way we see the world and ourselves (Fox et al. 2015).
Gratitude, the brain, and social connection
The correlation between oxytocin function and expressions of gratitude demonstrates the importance of gratitude in social bonding (Algoe & Way, 2014).
Brain activity and hormones are released when individuals report being grateful for wellbeing and when they hear stories about compassion for emotional pain (Algoe & Way, 2014).
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Psychological & Physiological Benefits of Gratitude
We all know the feeling of gratitude. The warm fuzzy feeling of being appreciated or expressing that appreciation to someone else.
As researchers explore various aspects of neurology and human behavior, they are finding strong connections between the mind, emotions, and actions.
The neuroscience of gratitude and its relationship with brain function demonstrate numerous psychological and physiological benefits.
Gratitude and resilience
Gratitude has been correlated with resilience and feelings of happiness. One study indicated that participants who felt more grateful and practiced gratitude journaling were also happier and emotionally stronger (McCanlies et al., 2018).
Gratitude can boost emotional resilience by focusing on positive things in life instead of toxic emotions like envy, jealousy, resentment, and anxiety.
This gratitude TED talk by Christina Costa provides a wonderful example of how gratitude can lead to resilience.
Kiss your brain: The science of gratitude - Christina Costa
Gratitude for stress
Committing to a daily gratitude practice may reduce negative emotions and provide a natural stress detox for the mind and body.
Studies on gratitude and appreciation found that participants experienced a reduction in cortisol levels (the stress hormone) and had better cardiac function (McCraty & Childre, 2004).
Participants that practiced gratitude were also more resilient to emotional setbacks and negative experiences (McCraty & Childre, 2004).
Practicing gratitude can help individuals handle stress better and rewire the brain to cope with difficult circumstances with more awareness and broader perception (McCraty & Childre, 2004).
Additionally, studies indicate that people who are grateful to God are healthier and have higher levels of stress resilience (Krause, 2006).
An experiment conducted on three groups of individuals, each team representing a particular age group, revealed that older adults who felt more grateful to God for their lives scored higher on a stress-tolerance index than others (Krause, 2006).
Gratitude and anxiety
There is evidence supporting a relationship between gratitude and anxiety (Lau & Cheng, 2011). In one study 83 Chinese adults were divided into three groups: one wrote gratitude notes and words of positivity, one wrote about their worries, and the third group was assigned a neutral task.
After the task completion, the groups were exposed to stimuli arousing death anxiety, an inevitable fear many individuals struggle with.
Participants in the first group who wrote gratitude notes showed fewer symptoms of death anxiety than the other two groups. A grateful attitude can help individuals attain acceptance and become less fearful of the future (Lau & Cheng, 2011).
This data implies that gratitude and gratitude journaling can reduce anxiety. Gratitude practices like journaling and group discussions are important parts of mental health interventions and life coaching regimes.
Gratitude reduces pain
Gratitude may reduce feelings of pain by regulating dopamine levels (Emmons & McCullough, 2003).
A study known as “Counting Blessings Versus Burdens” found a positive effect on physical wellbeing among participants with neuromuscular diseases (Emmons & McCullough, 2003).
Gratitude has the ability to improve affect in the present and also increases the likelihood that people will function optimally and feel good in the future (Emmons & McCullough, 2003).
Gratitude improves immunity
Gratitude research has demonstrated that individuals who have higher levels of trait gratitude have fewer common health complaints such as headaches, digestion problems, infections, dizziness, congestion, and sleep problems (Hazlett et al., 2021).
Practicing gratitude has also been shown to decrease physical symptoms such as head pain, sore muscles, and nausea. The authors believe that gratitude can downregulate threat responses from the amygdala, decreasing cellular inflammatory responses linked to health (Hazlett et al., 2021).
Gratitude improves sleep
Studies have shown that receiving and displaying simple acts of kindness and expressing gratitude activate the hypothalamus (Zahn et al., 2009). The hypothalamus regulates bodily mechanisms that control sleep.
Hypothalamic regulation triggered by gratitude helps us get deeper and healthier sleep naturally every day. Gratitude and kindness help promote better sleep and energetic mornings (Zahn et al., 2009).
Gratitude reduces depression
By reducing stress hormones and managing the autonomic nervous system functions, gratitude significantly reduces symptoms of depression (Emmons & McCullough, 2003).
At the neurochemical level, feelings of gratitude are associated with an increase in the neural modulation of the prefrontal cortex, the brain site responsible for managing negative emotions like guilt, shame, and violence (Emmons & McCullough, 2003).
As a result, people who have a regular gratitude practice may be more empathetic and positive-minded.
How to Practice Gratitude for Brain-Boosting Benefits
Since the neuroscience of gratitude confirms that gratitude can reshape the brain and change cognition, the key is finding ways to practice appreciation and gain mental benefits from it.
Simple daily actions or structured interventions and homework for clients can unlock the cognitive superpower.
Appreciate yourself
Gratitude should start with yourself. A simple practice of standing in front of the mirror and saying five good things you appreciate about yourself can do wonders for confidence and sparking joy.
This might include recognizing past achievements, present efforts, or talents and virtues. Compliment yourself with words like beautiful, loyal, disciplined, kind, and loving and notice how it makes you feel.
Gratitude journal
Gratitude journals provide a personal space to write down the things you are thankful for. Reflecting and recording gratitude forces individuals to consciously focus on good things rather than the bad.
There is power in words. A gratitude journal can look something like this:
Additional tips for gratitude journaling:
Make journal entries specific.
Provide depth and detail.
Write regularly and stay consistent.
Think about negative things that have been avoided, not just positive gifts.
Remember the good events and savor the emotions that come with the practice of journaling. For more ideas, this sister article offers journaling prompts to help you express your gratitude.
Gratitude visits
Writing a thank-you letter to someone who has made a positive impact on your life can be beneficial for both the giver and the receiver.
However, gratitude visits may have an even more powerful effect on wellbeing. These involve writing a gratitude letter, delivering the letter, and reading it out loud to the recipient.
Gratitude visits have been found to produce positive effects for individuals in the short and long term. These include general levels of happiness, an increased sense of purpose and wellbeing, and improved relationships (Stefan et al., 2021).
Gratitude meditation and exercises
Taking time to pause, be present, and reflect on specific people and aspects of life can offer powerful benefits for the mind and body. Gratitude meditation can be done daily but may provide benefits in as little as one session.
In addition, there is a wealth of gratitude exercises that can be implemented into therapy and coaching sessions or given to clients as homework.
This five-minute meditation ends with a reflection of gratitude:
5 Minute guided meditation for gratitude - The Mindful Movement
How Helping Professionals Can Use Gratitude in Therapy & Coaching
Not only can gratitude be directly implemented into therapy and coaching, but it can be added in subtle ways as well.
Clients can start increasing gratitude by developing more awareness and taking time to pause and observe. Start sessions with a quick body scan or mindful breathing exercise, and then ask them to reflect on one thing they are grateful for since the last meeting.
Teaching clients to live lives that are more grateful can induce the neurobiological benefits discussed in this article. Here are three options:
Encourage clients to create visual reminders to be grateful on a daily basis. This might include positive affirmations, pictures of people and places they are grateful for, or reminders of past success, accomplishments, or fond memories.
Reinforce grateful language in sessions. Grateful individuals use words like gifts, givers, blessing, fortunate, and abundance (McCraty & Childre, 2004). Focus on topics, ideas, and language that are inherently good, rather than inherently bad.
Use gratitude exercises such as journaling, writing out things they are grateful for, and gratitude meditations to help clients deal with specific issues, develop resilience, and improve relationships.
The Future of Gratitude Research in Neuroscience
The understanding of neuroscience and gratitude continues to evolve. It is evident that the emotion of gratitude has a direct relationship with the body and brain (Hazlett et al., 2021).
Future research may examine neurotechnology, brain–computer devices, artificial intelligence, and neurostimulation to explore various facets of the brain and gratitude. It may be possible to increase an individual’s natural capacity to experience gratitude and the mental, emotional, and physical benefits it can offer.
Exploring the long-term effects of gratitude can also help therapists and coaches create strategies and treatment plans to harness its benefits for specific interventions.
17 Exercises To Nurture Gratitude & Appreciation
Empower others with more hope, satisfaction, and fulfilling relationships with these 17 Gratitude & Appreciation Exercises [PDF] that harness the powerful benefits of gratitude.
PositivePsychology.com offers a wide selection of resources that clients can use to start or enhance a regular gratitude practice and experience its benefits.
As mentioned, a gratitude journal worksheet is a simple and excellent way to begin. This worksheet provides specific prompts that can be used as bullet points and expanded into more depth and detail.
This reflection worksheet can be more than just exploring who clients are, where they come from, and what their values are. Clients can use each of the headings to reflect on three things they are grateful for in the specific area.
Much like the gratitude visit described earlier, this worksheet encourages and guides clients to show appreciation for people in their life. It provides a variety of ideas for demonstrating gratitude.
If you’re looking for more science-based ways to help others harness the benefits of gratitude, consider this collection of 17 validated gratitude tools for practitioners. Use them to help others shift to a more positive mindset and experience the joys of life more deeply.
A Take-Home Message
The neuroscience of gratitude shows how such a simple yet powerful emotion has the capacity to change our minds, relationships, and general wellbeing.
While we experience gratitude subjectively, the feeling influences neural pathways that affect physiological and psychological health.
Practicing gratitude is synonymous with expressing our feelings for others and ourselves. By using simple words of love and praise, we make others feel good, and we will also feel a lot better about ourselves and our lives.
Gratitude can provide renewed insight and hope for every day.
The parasympathetic nervous system is activated when an individual experiences gratitude. This can lower heart rate and promote relaxation and clarity (Fox et al., 2015). Because gratitude decreases activity in the amygdala, it can lower cortisol and create a calm and balanced state, which increases happiness. The amygdala is the brain’s fear center, so this decreased activation makes it easier to experience positive emotions such as joy and contentment (Hazlett et al., 2021).
What are the neurological benefits of gratitude?
The consistent practice of gratitude can rewire neural pathways that shift thinking patterns into a more positive frame. It also activates the nucleus accumbens (a reward center), which improves motivation (Fox et al., 2015).
Which part of the brain is more active when we feel gratitude?
Gratitude activates the medial prefrontal cortex. This area of the brain controls decision-making, emotional regulation, and social cognition. Gratitude interventions have also been shown to reduce activity in the amygdala, the brain’s fear and emotion center, helping regulate stress and anxiety response (Hazlett et al., 2021).
References
Algoe, S. & Way, B. (2014). Evidence for a role of the oxytocin system, indexed by genetic variation in the social bonding effects of expressed gratitude. Social Cognitive and Affective Neuroscience, 9(12), 1855–1861. https://doi.org/10.1093/scan/nst182
Emmons, R. A. & McCullough, M. E. (2003). Counting blessings versus burdens: An experimental investigation of gratitude and subjective well-being in daily life. Journal of Personality and Social Psychology, 84(2), 377–389.
Emmons, R. & McCullough, M. (2004). The psychology of gratitude (series in affective science). Oxford University Press.
Fox, G., Kaplan, J., Damasio, H. & Damasio, A. (2015). Neural correlates of gratitude. Frontiers in Psychology, 6, 149–154.
Hazlett, L., Moieni, M., Irwin, M., Haltom, K., Jevtic, I., Meyer, M., Breen, E., Cole, S. & Eisenberger, N. (2021). Exploring neural mechanisms of the health benefits of gratitude in women: A randomized controlled trial. Brain, Behavior, and Immunity, 95, 444–453. https://doi.org/10.1016/j.bbi.2021.04.019
McCanlies, C., Gu, K., Andrew, E. & Violanti, M. (2018). The effect of social support, gratitude, resilience and satisfaction with life on depressive symptoms among police officers following Hurricane Katrina. International Journal of Social Psychiatry, 64(1), 63–72. https://doi.org/10.1177/0020764017746197
McCraty, R. & Childre, D. (2004). The grateful heart: The psychophysiology of appreciation. In R. Emmons & E. McCullough (Eds.), The psychology of gratitude (pp. 230–255). Oxford University Press.
Russell, E. & Fosha, D. (2008). Transformational affects and core state in AEDP: The emergence and consolidation of joy, hope, gratitude and confidence in (the solid goodness of) the self. Journal of Psychotherapy Integration, 18(2), 167–190. https://doi.org/10.1037/1053-0479.18.2.167
Stefan, D., Lefdahl, E., Alayan, A., Decker, M., Kulwicki, T., Parallel, J. & Wittwer, J. (2021). The impact of gratitude letters and visits on relationships, happiness, wellbeing and meaning in graduate students. Journal of Positive School Psychology, 5(2), 110–126.
Wong, Y., Owen, J., Gabana, N., Brown, J., McInnis, S., Toth, P. & Gilman, L. (2018). Does gratitude writing improve the mental health of psychotherapy clients? Evidence from a randomized controlled trial. Psychotherapy Research, 28(2), 192–202. https://doi.org/10.1080/10503307.2016.1169332
Zahn, R., Garrido, G., Moll, J. & Grafman, J. (2014). Individual differences in posterior cortical volume correlate with proneness to pride and gratitude. Social Cognition and Affective Neuroscience, 9(11), 1676–1683. https://doi.org/10.1093/scan/nst158
Zahn, R., Moll, J., Iyengar, V., Huey, E., Tierney, M., Krueger, F. & Grafman, J. (2009). Social conceptual impairments in frontotemporal lobar degeneration with right anterior temporal hypometabolism. Brain, 132(3), 604–616. https://doi.org/10.1093/brain/awn343
Zahn, R., Moll, J., Paiva, M., Garrido, G., Krueger, F. & Huey, E. (2008). The neural basis of human social values: Evidence from functional MRI. Cerebral Cortex, 19(2), 276–283. https://doi.org/10.1093/cercor/bhn080
About the author
Dr. Melissa Madeson, Ph.D., believes in a holistic approach to mental health and wellness and uses a person-centered approach when working with clients.
Currently in full-time private practice, she uses her experience with performance psychology, teaching, and designing collegiate wellness courses and yoga therapy to address a range of specific client needs.
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What our readers think
Joyce Ann West
on October 24, 2025 at 01:55
I love this article and practice gratefulness often. This article is a reminder that I should practice being grateful 24/7.
Hello,
this post is so well written with all scientific information needed and pieces of advice. Is it possible to have it in pdf to be printed. I’m a GP and I’d love to give it to colleagues or patients.
Julia Poernbacher, M.Sc.
on December 19, 2024 at 19:02
Hi Marie-Eve,
Glad you found this post helpful. While we don’t currently have an option to download our posts, you are very welcome to share them with others. If you scroll to the end of the post and respond positively to the question ‘How useful was this article to you?’ several sharing options will become available to you.
This article is an eye opening and very catchy also. We should know the impact, very vast and sky touching with a small practice of GRATITUDE. Thanking authors.
Gratitude is a powerful human emotion.
Science has shown that aspects of gratitude have specific effects on the brain. For example, one study found that making moral decisions about gratitude activated the right anterior superior temporal cortex (Zahn et al., 2008).
The understanding of neuroscience and gratitude continues to evolve. It is evident that the emotion of gratitude has a direct relationship with the body and brain (Hazlett et al., 2021).
What our readers think
I love this article and practice gratefulness often. This article is a reminder that I should practice being grateful 24/7.
Great article, keep up the good work.
This article has been such a great resource for me when working with young adults.
Thank you for the additional information received that will assist in my Emotional Intelligence class and my Life Coaching. With Gratitude
Hello,
this post is so well written with all scientific information needed and pieces of advice. Is it possible to have it in pdf to be printed. I’m a GP and I’d love to give it to colleagues or patients.
Hi Marie-Eve,
Glad you found this post helpful. While we don’t currently have an option to download our posts, you are very welcome to share them with others. If you scroll to the end of the post and respond positively to the question ‘How useful was this article to you?’ several sharing options will become available to you.
Hope this helps!
Warm regards,
Julia | Community Manager
This article is an eye opening and very catchy also. We should know the impact, very vast and sky touching with a small practice of GRATITUDE. Thanking authors.